Evidence map›Paper›PMID 42111347›Full record

ArticleFrontiers in physiology2026

Hemorheological and microcirculatory effects of Pentaglobin therapy in an experimental model of fulminant sepsis.

Adam Attila Matrai, Balazs Ujhelyi, Adam Varga, Sandor Richard Zahorszki, David Martin Adorjan, Zoltan Toth, Norbert Nemeth, Bela Fulesdi, Adam Deak

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Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam Attila Matrai *Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Balazs Ujhelyi *Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Adam VargaDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Sandor Richard ZahorszkiDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
David Martin AdorjanDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Zoltan TothDepartment of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Norbert NemethDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Bela Fulesdi *Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Adam Deak *Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Sepsis is a life-threatening syndrome characterized by dysregulated immune response to infection and multi-organ dysfunction. One of the key components of this condition is microcirculatory dysfunction. The aim of our study was to evaluate the effects of IgM-enriched immunoglobulin (Pentaglobin, PG) on microcirculation and hemorheological parameters in a porcine model of fulminant sepsis induced by intravenous Escherichia coli ( Methods: Thirty female juvenile pigs were randomized into four groups: Control, Results: The microvascular flow index reached its highest values in the Discussion: Fulminant sepsis resulted in severe microcirculatory and hemodynamic disturbances. Pentaglobin therapy mitigated the decline in tissue perfusion, attenuated the elevation of blood viscosity and red blood cell aggregation.

Indexed as

fulminant sepsishemorheologymicrocirculationPentaglobinred blood cell aggregationred blood cell deformability

Identifiers

PMID42111347
PMCPMC13152774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.