Rice Bran Arabinoxylan Compound and Tryptophan Metabolism on Quality of Life of Cancer Patients: A Secondary Analysis of the RBAC-QoL Study.

Soo Liang Ooi, Benjamin Kimble, Benjamin S Pak, Peter S Micalos, Sok Cheon Pak

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Article in International journal of tryptophan research : IJTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Soo Liang OoiSchool of Dentistry and Medical Sciences, Charles Sturt University, Bathurst, NSW, Australia.ORCID https://orcid.org/0000-0002-0534-3673

Benjamin KimbleSydney School of Veterinary Science, The University of Sydney, NSW, Australia.

Benjamin S PakThe Centre for Molecular Oncology, School of Biomedical Sciences, The University of New South Wales, Sydney, NSW, Australia.

Peter S MicalosSchool of Dentistry and Medical Sciences, Charles Sturt University, Port Macquarie, NSW, Australia.

Sok Cheon PakSchool of Dentistry and Medical Sciences, Charles Sturt University, Bathurst, NSW, Australia.ORCID https://orcid.org/0000-0001-8510-5781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tryptophan metabolism, with its breakdown along the kynurenine pathway, is linked to the diminishing quality of life (QoL) of cancer patients. Rice bran arabinoxylan compound (RBAC) is a plant-based immunomodulator shown to improve the global QoL and functioning beyond the placebo during systemic cancer treatment in a randomised-controlled trial (RBAC-QoL study). However, whether RBAC improved QoL through the tryptophan pathway, and the role of tryptophan and its kynurenine metabolite in these QoL outcomes, were not previously investigated. In this study, serum tryptophan and kynurenine were analysed in samples collected from the RBAC-QoL study using a validated liquid chromatography method with ultraviolet and fluorescence detection. This secondary analysis was conducted using repeated-measures ANOVA, Spearman's correlation, and linear mixed models. The results show that RBAC supplementation had no statistically significant effect on tryptophan metabolism compared to the placebo. Tryptophan significantly (

Indexed as

biobranblood markersL-kynurenineL-tryptophanpatient-reported outcome measuresQLQ-C30

Identifiers

PMID42111330

DOI10.1177/11786469261441904

PMCPMC13150091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.