Evidence map›Paper›PMID 42111313›Full record

ArticleJournal of multimorbidity and comorbidity

Validation of the Global Treatment Burden Question (GTBQ): A novel single-item measure for use in clinical and research settings.

Chloe Gamlin, Rachel Johnson, Lauren J Scott, Anastasiia Kovalenko, Rebecca Goulding, Thomas Brain, Simon Chilcott, Thomas Blakeman, Jose M Valderas, Simon D S Fraser and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of multimorbidity and comorbidity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chloe GamlinCentre for Academic Primary Care, University of Bristol, Bristol, UK.ORCID https://orcid.org/0009-0006-5555-1469
Rachel JohnsonCentre for Academic Primary Care, University of Bristol, Bristol, UK.
Lauren J ScottNational Institute for Health Research Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
Anastasiia KovalenkoCentre for Academic Primary Care, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-4299-3587
Rebecca GouldingDivision of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-0716-5126
Thomas BrainCentre for Academic Primary Care, University of Bristol, Bristol, UK.
Simon ChilcottCentre for Academic Primary Care, University of Bristol, Bristol, UK.
Thomas BlakemanCentre for Primary Care and Health Services Research, The University of Manchester, Manchester, UK.
Jose M ValderasExeter Collaboration for Academic Primary Care, University of Exeter, Exeter, UK.
Simon D S FraserSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-4172-4406
Polly DuncanCentre for Academic Primary Care, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-2244-3254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A single-item, global measure could be valuable for identifying patients with high treatment burden within clinical practice and research. Aim: To validate a novel single-item global measure, named the 'Global Treatment Burden Question' (GTBQ). Methods: GTBQ: "how hard have you found the work of looking after your health conditions?" (responses "not hard", "slightly hard", "moderately hard", "very hard", "extremely hard"). Included participants: 18-65 years, ≥2 long-term conditions. Baseline survey: GTBQ, socio-demographics, Multimorbidity Treatment Burden Questionnaire (MTBQ), quality of life, health literacy. Follow-up survey: GTBQ. Electronic health records data: long-term conditions, consultations. Spearman's Rank correlation (R Results: 974 (mean age 51) and 97 participants returned baseline and follow-up surveys, respectively. Responses were positively skewed with 22% reporting no burden at baseline. GTBQ scores were positively associated with global MTBQ scores (R Conclusion: This novel single-item measure has demonstrated good content and construct validity, moderate test-retest reliability, and strong ability to discriminate between high and non-high treatment burden.

Indexed as

multimorbiditytreatment burdenvalidation

Identifiers

PMID42111313
PMCPMC13153489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.