Evidence map›Paper›PMID 42111301›Full record

ArticleBrain circulation

Exacerbation of hemorrhagic stroke and impaired hemostasis in mice deficient of the integrated stress response kinase heme-regulated inhibitor.

Lukasz P Slomnicki, Rachel L Owens, Emily R Hodges, Jordan McNeely, Darlene A Burke, Julia H Chariker, Eric Christian Rouchka, Sujata Saraswat Ohri, Dale Ding, Michal Hetman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lukasz P SlomnickiKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Rachel L OwensDepartment of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Emily R HodgesKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Jordan McNeelyKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Darlene A BurkeKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Julia H CharikerDepartment of Neuroscience Training, University of Louisville, Louisville, KY, USA.
Eric Christian RouchkaKentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, Louisville, KY, USA.
Sujata Saraswat OhriKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Dale DingDepartment of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Michal HetmanKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
NIGMS NIH HHS P20 GM103436
6 · The paper itself

Abstract

backgroundHeme-regulated inhibitor (HRI/EIF2AK1) is a protein kinase that initiates the integrated stress response (ISR) following mitochondrial damage and/or oxidative stress. Dependent on a context, ISR may promote death or recovery of cells under stress. This study was initiated to determine HRI contributions to brain damage after experimental intracerebral hemorrhage (ICH) where oxidative toxicity of hemoglobin is a major trigger of neural cell loss. MATERIALS AND

methodsPublicly available transcriptomic data from a mouse model of ICH were analyzed using standard bioinformatic tools.

resultsISR transcripts were robustly overrepresented in the transcriptome of the peri-hematoma region of wild-type mice at 1-day post-ICH induction, suggesting acute ISR activation. After ICH,

conclusionsWhile ISR is activated by ICH and may play a role in secondary injury, impaired hemostasis is a likely driver of enhanced ICH severity in

Indexed as

Hemostasisintegrated stress responseintracerebral hemorrhageneuroprotectionsecondary injury

Identifiers

PMID42111301
PMCPMC13152244

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.