ReviewBrain circulation
A narrative review of neuroprotective effects of albumin: The underlying mechanisms and therapeutic prospects in ischemic stroke.
Review in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- CRP-albumin-lymphocyte index and multisystem diseases: a phenome-wide Mendelian randomization study.Molecular genetics and genomics : MGG · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Albumin, the most prevalent protein in human plasma, has demonstrated neuroprotective properties in preclinical studies. However, its efficacy in clinical trials remains controversial. We summarized the neuroprotective mechanisms of albumin and analyzed the possible reasons behind this controversy. Furthermore, hypoalbuminemia has strong predictive effects, which have always been overlooked. Therefore, we summarized the predictive effects of hypoalbuminemia and highlighted its importance. Finally, brain no-reflow and glymphatic system are the two factors influencing the prognosis of patients with acute ischemic stroke. We investigated the relationship between albumin and these factors, proposing possible mechanisms for the neuroprotective effects of albumin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.