Evidence map›Paper›PMID 42111267›Full record

ArticleFrontiers in cell and developmental biology2026

Branch site mutated mice revealed distinct roles of two Runx2 isoforms in bone development.

Qing Jiang, Manyu Zhang, Haoyunyan Jin, Ziheng Zhang, Chiharu Sakane, Yuki Matsuo, Simeng Lai, Wen Zhang, Huilin Yang, Toshihisa Komori and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qing Jiang *Institute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.
Manyu Zhang *Institute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.
Haoyunyan JinInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.
Ziheng ZhangInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.
Chiharu SakaneResearch Center for Biomedical Models and Animal Welfare, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yuki MatsuoDepartment of Molecular Tumor Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Simeng LaiInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.
Wen ZhangInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.
Huilin YangInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.
Toshihisa KomoriDepartment of Molecular Tumor Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Xin QinInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Runx2 is a key regulator of osteoblast differentiation and chondrocyte maturation. However, the distinct functions of the two functional isoforms remain to be clarified. Transcription of two isoforms, Runx2-I and Runx2-II, starts from the proximal and distal promoters upstream of exons 2 and 1, respectively. To investigate the functions of the two isoforms, we generated a novel mouse model (

Indexed as

cleidocranial dysplasiaendochondral ossificationosteoblast differentiationRunx2-IRunx2-IIsuture mesenchymal cell proliferation

Identifiers

PMID42111267
PMCPMC13152850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.