Evidence map›Paper›PMID 42111199›Full record

ArticleiScience2026

Aluminum exposure impairs nuclear envelope breakdown for mouse zygote formation.

Xiao-Ting Yu, Xing-He Ke, Zi-Jian Wu, Zhen-Hui Fu, Rui-Jie Ma, Xuan Wu, Meng-Meng Tang, Shao-Chen Sun, Lin-Lin Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao-Ting YuKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Reproductive Medicine of Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Xing-He KeKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Reproductive Medicine of Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Zi-Jian WuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Zhen-Hui FuKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Reproductive Medicine of Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Rui-Jie MaCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Xuan WuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Meng-Meng TangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Shao-Chen SunKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Reproductive Medicine of Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.
Lin-Lin HuKey Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Reproductive Medicine of Guangxi Medical and Health Key Discipline Construction Project, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aluminum exposure ubiquitously presents in the environment and its toxicity elicits oxidative stress and metabolic disorders. In the present study, we reported that aluminum exposure disturbed zygote formation with mouse model. We found that aluminum-exposed mouse zygotes exhibited nuclear envelope breakdown defects, indicative of failed zygote development. Further analyses revealed that microtubules decreased with aberrant tubulin acetylation, and actin dynamics was disturbed, indicating the cytoskeleton impairment. This further leads to DNA damage and disturbed cell cycle in zygotes. Moreover, mitochondrial dysfunction was observed, which triggers oxidative damage and apoptosis. These defects were closely linked to the aberrant distribution and function of the organelles for protein modification and intracellular transport in zygotes. Collectively, our results indicate that aluminum exposure compromises cytoskeletal integrity and cell cycle progression, which may be due to mitochondria-based oxidative damage and apoptosis for organelle function, and ultimately disrupts nuclear envelope breakdown for zygote formation in mice.

Indexed as

cell biologydevelopmental biologyenvironmental toxicology

Identifiers

PMID42111199
PMCPMC13157191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.