Evidence map›Paper›PMID 42111194›Full record

ArticleiScience2026

Hmgcs1 regulates cholesterol synthesis and promotes nerve fiber repair after spinal cord injury.

Yingfan Pei, Guoying Feng, Yaorui Hu, Jiaran Tang, Naili Zhang, Shuai Zhou, Chunlei Zhang, Fei Huang, Luping Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingfan PeiInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.
Guoying FengInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.
Yaorui HuDepartment of Neurobiology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Jiaran TangInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.
Naili ZhangInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.
Shuai ZhouInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.
Chunlei ZhangInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.
Fei HuangInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.
Luping ZhangInstitute of Neurobiology, Binzhou Medical University, Yantai, Shandong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a severe neurological disorder characterized by axonal damage, myelin destruction, and motor and sensory dysfunction. This study employed mass spectrometry-based proteomic analysis to systematically identify differentially expressed proteins (DEPs) between sham-operated and SCI rats at post-injury time points (1, 3, 7, 14, and 28 days). 3-Hydroxy-3-methylglutaryl-CoA synthase 1 (HMG-CoA synthase 1, Hmgcs1) was identified as a key candidate protein. To investigate the role of Hmgcs1 in SCI repair, we utilized viral vector technology for functional studies both

Indexed as

Health sciencesMolecular neuroscienceNeuroscienceSystems neuroscience

Identifiers

PMID42111194
PMCPMC13156602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.