UBE2M-mediated EGFR neddylation drives keratinocyte proliferation in psoriasis.

Xiang Lin, Qixia Wang, Linlin Xu, Yibo Wang, Yixuan Fu, Zhenzhen Yan, Shuhong Huang, Ningning Dang

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiang LinDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Qixia WangSchool of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Linlin XuDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Yibo WangDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Yixuan FuDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Zhenzhen YanDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Shuhong HuangDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Ningning DangDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Basal keratinocytes (KCs) exhibit enhanced proliferative activity alongside severely impaired differentiation in psoriasis. Accumulating evidence has implicated dysregulation of the neddylation pathway in various human diseases; however, its role in psoriasis remains largely unexplored. In this study, we assessed global neddylation levels and the expression of neddylation-associated enzymes in both human psoriatic lesions and imiquimod (IMQ)-induced murine models of psoriasis. Our results revealed a significant upregulation of the E2-conjugating enzyme UBE2M in psoriatic lesions. UBE2M promotes psoriatic pathogenesis by enhancing keratinocyte proliferation and inflammatory responses. Both genetic and pharmacological inhibition of UBE2M suppressed psoriasis-like development

Indexed as

cellmolecular interactiontherapy

Identifiers

PMID42111190

DOI10.1016/j.isci.2026.115784

PMCPMC13156996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.