A multicenter observational study of the association between systemic immune inflammation index and adenomyosis.

Chaoyan Yue, Ying Zhang, Shuai Qiu, Wenhui Wang, Fenyong Sun, Feng Xing, Ying Wang

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Chaoyan YueDepartment of Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China.

Ying ZhangDepartment of Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China.

Shuai QiuDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.

Wenhui WangDepartment of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.

Fenyong SunDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.

Feng XingDepartment of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.

Ying WangDepartment of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai 200235, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenomyosis involves aberrant inflammation and immune dysregulation in its pathogenesis. This multicenter study investigated the association between the systemic immune inflammation index (SII) and adenomyosis risk among 74,900 participants undergoing laparoscopic surgery. In this retrospective analysis of 9,333 patients and 65,567 controls, elevated SII levels-after adjustment for 10 confounders including intrauterine device (IUD) use, cesarean history, and hypertension-showed a consistent, stepwise association with increased adenomyosis risk, whether SII was analyzed as a categorical or continuous variable. Notably, this upward trend plateaued when SII reached or exceeded 1,500. Subgroup analyses revealed that this significant positive association persisted independently in women with a body mass index (BMI) < 24 kg/m

Indexed as

health sciences

Identifiers

PMID42111181

DOI10.1016/j.isci.2026.115721

PMCPMC13157182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.