ArticleiScience2026
Joint analysis of hemoglobin-to-RDW and creatinine-to-albumin ratios for mortality prediction in critical heart failure.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Hemoglobin-to-red cell distribution width ratio (HRR) and creatinine-to-albumin ratio (CAR) are simple and easily obtainable biomarkers reflecting anemia/inflammation and renal and nutritional status, respectively. We investigated whether these markers predict mortality in intensive care unit (ICU) patients with heart failure (HF). In a retrospective analysis of 31,454 ICU cases from three critical care databases (MIMIC-IV, MIMIC-III, eICU-CRD) and an independent hospital cohort, Cox regression models assessed associations with 28-day all-cause mortality (primary outcome) and 90-day, 180-day, and 1-year mortality. Higher HRR was independently associated with lower 28-day mortality, whereas higher CAR predicted higher 28-day mortality risk. These associations remained consistent at 90-day, 180-day, and 1-year follow-up. Patients with combined low HRR and high CAR had the greatest 28-day mortality risk. HRR and CAR thus serve as independent predictors of short-term mortality in ICU patients with HF, and their joint assessment may improve early risk stratification and management.
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