ArticleFrontiers in cardiovascular medicine2026
Clinical characteristics and outcomes of lean diabetes mellitus in patients with moderate and severe aortic stenosis.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lean diabetes mellitus (DM), defined as the presence of DM in patients with low-normal body mass index (BMI), is an emerging concept associated with poorer cardiovascular and all-cause outcomes. We aimed to describe the clinical characteristics of aortic stenosis (AS) patients with concomitant lean DM, an understudied metabolic profile, and to evaluate its clinical relevance. Methods: In this retrospective cohort study involving 315 moderate and severe AS patients, identified from an echocardiographic database at a tertiary medical centre between September 2011 and December 2015, patients were stratified based on obesity (BMI ≥ or <23 kg/m Results: The mean age was 72.2 ± 13.1 years old, and 52.4% were female. Among the 315 patients with moderate and severe AS, 47 (14.9%) were lean DM, 24.4% were lean without DM, 30.0% were non-lean with DM, and 33.7% were non-lean without DM. Compared with non-lean DM patients, AS patients with lean DM were older ( Conclusion: The presence of lean DM in moderate and severe AS patients portends a higher risk of MACE, and represents a high-risk phenotype that may warrant closer surveillance and earlier intervention.
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