ArticleFrontiers in cardiovascular medicine2026
Triglyceride levels and all-cause mortality in patients with left main coronary artery disease undergoing percutaneous coronary intervention.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Backgrounds: Triglycerides (TG) and triglyceride-rich lipoproteins contribute to the development and progression of atherosclerosis. However, the prognostic value of TG levels in patients with left main coronary artery disease (LMCAD) remains unexplored. This study aimed to examine the association between TG levels and long-term mortality within this population. Methods: We conducted a single-center retrospective study of 2,778 patients with LMCAD undergoing percutaneous coronary intervention (PCI). We modeled the association between TG levels and the hazard ratio (HR) for mortality using restricted cubic splines (RCS). An optimal TG cutoff for stratification was identified using the maximum selected rank statistic, and patients were then divided into two groups. We assessed the proportional hazards assumption with plots of Schoenfeld residuals. The primary endpoint was all-cause death. Secondary endpoints included cardiovascular death, myocardial infarction, stroke, stent thrombosis, and target vessel revascularization. Results: Over a mean follow-up of 47.4 ± 30.3 months, 351 (12.6%) patients died, including 207 cardiovascular deaths. Restricted cubic spline analysis showed a linear inverse relationship between TG levels and all-cause mortality. An optimal TG cutoff of 0.93 mmol/L was identified, dividing patients into high-TG ( Conclusion: Our findings indicate that low TG levels are an independent prognostic factor for all-cause mortality among LMCAD patients undergoing PCI.
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