ArticleFrontiers in neurology
Lymphocyte-albumin-neutrophil ratio predicting short-term and long-term mortality risk in elderly patients with delirium: an analysis based on the MIMIC-IV database.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Inflammatory response and nutritional status are closely related to the prognosis of critically ill patients, especially in elderly patients with delirium, where the situation is more complex. This study aims to explore the relationship between the Lymphocyte-Albumin-Neutrophil Ratio (LANR) and short- and long-term mortality risks in elderly delirium patients, providing valuable insights for clinical management. Methods: This study utilized the MIMIC-IV ICU public database to identify elderly delirium patients based on ICD-9 and ICD-10 codes. First, a qualitative approach was employed using Restricted Cubic Spline (RCS) analysis to visually illustrate the potential relationship between LANR and 30-day and 365-day mortality rates. Second, from a quantitative perspective, a Cox proportional hazards model was used for multivariable regression analysis to assess the independent effect of LANR on short- and long-term mortality risks after adjusting for other confounding factors. Additionally, to further explore heterogeneity, subgroup analyses were conducted, and forest plots were generated to examine potential significant interactions. Results: A total of 1,804 elderly delirium patients were extracted from the MIMIC-IV database, with a mean age of 77.6 ± 7.9 years and an ICU length of stay of 3.3 days [IQR 1.8-6.7 days]. Restricted cubic spline analysis revealed a linear relationship between LANR and 30-day mortality risk reduction in elderly delirium patients ( Conclusion: The inflammatory marker LANR is closely associated with increased short- and long-term ICU mortality risk in elderly delirium patients, highlighting its potential as a prognostic tool in clinical practice.
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