ArticleFrontiers in neurology
Temporal dynamics of diffusion kurtosis imaging parallels astroglial GFAP expression in a non-traumatic spinal cord injury animal model of ischemia-reperfusion.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Spinal cord ischemia-reperfusion (I/R) injury triggers rapid secondary degeneration, yet sensitive noninvasive markers that reflect early astroglial and microstructural alterations remain scarce. This study aimed to delineate the temporal changes in GFAP immunoreactivity as an indicator of astroglial response following spinal cord I/R and to determine how these pathological dynamics correspond to diffusion kurtosis imaging (DKI) metrics in a rabbit model. Methods: Forty-five male New Zealand White rabbits were randomized into a Sham group or four I/R groups with reperfusion durations of 6 h, 24 h, 72 h, and 7 d ( Results: Following I/R, GFAP immunoreactivity increased progressively and reached its highest mean value at 72 h, and this temporal pattern was confirmed by Western blot analysis ( Conclusion: GFAP immunoreactivity after spinal cord I/R follows a well-defined temporal trajectory that closely parallels DKI-derived microstructural alterations, supporting the utility of DKI parameters as noninvasive biomarkers that reflect astroglial response dynamics during early spinal cord I/R injury.
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