Evidence map›Paper›PMID 42110985›Full record

ArticleBiomedical optics express2026

Slide-free, point-of-care imaging of core needle biopsies for rapid histologic assessment.

Dena Sayrafi, Sarah Rezapourdamanab, Eugenie Dulout, Richard Levenson, Eric Seibel, Romil Saxena, Alexander Borowsky, Michael C Larson, Farzad Fereidouni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dena SayrafiDepartment of Pathology and Laboratory Medicine, Emory University, 1750 Haygood Dr NE, Atlanta, GA, 30307, USA.ORCID https://orcid.org/0009-0007-9856-4099
Sarah RezapourdamanabDepartment of Pathology and Laboratory Medicine, Emory University, 1750 Haygood Dr NE, Atlanta, GA, 30307, USA.
Eugenie DuloutDepartment of Pathology and Laboratory Medicine, Emory University, 1750 Haygood Dr NE, Atlanta, GA, 30307, USA.
Richard LevensonDepartment of Pathology and Laboratory Medicine, UC Davis Health, 4400 V Street, Sacramento, CA 95817, USA.ORCID https://orcid.org/0000-0002-0112-6823
Eric SeibelDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.
Romil SaxenaDepartment of Pathology and Laboratory Medicine, Emory University, 1750 Haygood Dr NE, Atlanta, GA, 30307, USA.
Alexander BorowskyDepartment of Pathology and Laboratory Medicine, UC Davis Health, 4400 V Street, Sacramento, CA 95817, USA.
Michael C LarsonDepartment Radiology, UC Davis Health, 4860 Y Street, Sacramento, CA 95817, USA.
Farzad FereidouniDepartment of Pathology and Laboratory Medicine, Emory University, 1750 Haygood Dr NE, Atlanta, GA, 30307, USA.ORCID https://orcid.org/0000-0001-6790-0888

Funding

GigaFIBI; rapid, large-format histology-resolution imaging for Intraoperative assessment of breast lumpectomy marginsR01CA277527 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Farzad Fereidouni · 2023 to 2026
$2.4M
NCI NIH HHS R01 CA277527
6 · The paper itself

Abstract

Histological evaluation of core needle biopsies (CNB) using formalin-fixed, paraffin-embedded (FFPE) slides remains slow and resource-intensive, with up to 15% of samples identified as inadequate only after post-processing review. We introduce CoreLab, a compact optical imaging system designed for real-time, slide-free imaging of fresh CNB specimens using fluorescence-imitating brightfield imaging (FIBI). CoreLab integrates tissue collection, rapid H&E staining, and optical imaging into a single workflow, allowing intact biopsy cores to be imaged within five minutes of acquisition without sectioning, compression, or glass mounting, while preserving specimen integrity and supporting downstream histology compatibility. Preliminary FIBI imaging across multiple tissue types, including breast, liver, kidney, and adipose tissue, showed high structural correspondence with standard histology. CoreLab demonstrates the feasibility of intra-procedural, slide-free visualization of intact biopsy specimens. It has the potential to support immediate biopsy adequacy assessment, and provide preliminary histological insight, thereby reducing the need for repeat procedures and accelerating clinical decision-making.

Identifiers

PMID42110985
PMCPMC13155815

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.