Evidence map›Paper›PMID 42110982›Full record

ArticleBiomedical optics express2026

Phase diversity improves retinal image quality in adaptive optics scanning light ophthalmoscopy.

Yongyi Cai, Eryk Druszkiewicz, Sara S Patterson, Keith Parkins, Juliette E Mcgregor, William H Merigan, James R Fienup, David R Williams

Abstract read
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yongyi CaiCenter for Visual Science, University of Rochester, Rochester, NY 14621, USA.ORCID https://orcid.org/0009-0000-0016-5612
Eryk DruszkiewiczDepartment of Physics, University of Rochester, Rochester, NY 14621, USA.
Sara S PattersonDepartment of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID https://orcid.org/0000-0003-4574-3935
Keith ParkinsCenter for Visual Science, University of Rochester, Rochester, NY 14621, USA.
Juliette E McgregorCenter for Visual Science, University of Rochester, Rochester, NY 14621, USA.
William H MeriganCenter for Visual Science, University of Rochester, Rochester, NY 14621, USA.
James R FienupCenter for Visual Science, University of Rochester, Rochester, NY 14621, USA.ORCID https://orcid.org/0000-0001-5147-9435
David R WilliamsCenter for Visual Science, University of Rochester, Rochester, NY 14621, USA.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI MICHELE RUCCI · 1985 to 2026
$17.5M
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate EyeR01EY031467 · NEI · UNIVERSITY OF ROCHESTER · PI DAVID R WILLIAMS · 2021 to 2026
$3.5M
NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY031467
6 · The paper itself

Abstract

The quality of retinal images is compromised by aberrations that remain uncorrected even in confocal adaptive optics imaging. This study demonstrates phase diversity (PD), a computational imaging technique, to address residual aberrations and enhance image quality in adaptive optics scanning laser ophthalmoscopy (AOSLO). By using images of the same object obtained with and without deliberately added aberrations, PD computes and compensates for the effects of existing residual aberrations beyond those corrected by a closed-loop AO system. Experimental validation demonstrates that PD improves visualization of retinal microstructures, including cone mosaics and dendrites of fluorescently labeled retinal ganglion cells (RGCs).

Identifiers

PMID42110982
PMCPMC13155845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.