Evidence map›Paper›PMID 42110977›Full record

ArticleNeurobiology of stress2026

IBS stress reactivity phenotype is associated with blood transcriptome profiles and microstructural and functional brain changes.

Jennifer S Labus, Desiree R Delgadillo, Steve Cole, Chencai Wang, Swapna Joshi, Arpana Church, Bruce Naliboff, Lin Chang, Jonathan P Jacobs, Benjamin M Ellingson and 1 more

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Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jennifer S LabusOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.
Desiree R DelgadilloOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.
Steve ColeSemel Institute for Neuroscience and Human Behavior at UCLA, 760 Westwood Plaza, Los Angeles, CA, 90024, USA.
Chencai WangDepartment of Radiology at UCLA, 200 Medical Plaza, Los Angeles, CA, 90095, USA.
Swapna JoshiOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.
Arpana ChurchOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.
Bruce NaliboffOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.
Lin ChangOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.
Jonathan P JacobsOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.
Benjamin M EllingsonDepartment of Radiology at UCLA, 200 Medical Plaza, Los Angeles, CA, 90095, USA.
Emeran A MayerOppenheimer Center for Neurobiology of Stress and Resilience, Division of Digestive Diseases at UCLA, CHS 42-210 MC737818, 10833 Le Conte Ave, Los Angeles, CA, 90095-7378, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence suggests significant interindividual differences in stress reactivity (SR), but mechanisms and therapeutic implications of these differences are poorly understood. The aim of this study was to identify the biological basis of increased SR by investigating associations between a psychometric-based phenotype with blood transcriptomics profiles of unprovoked tonic increased sympathetic nervous system (SNS) activation and neuroimaging phenotypes in irritable bowel syndrome (IBS) participants and healthy controls (HCs). A cross-sectional study design, transcriptomics profiling, multimodal neuroimaging, and psychosocial assessments were obtained in 291 IBS participants and HCs. Unsupervised clustering was applied to derive High and Low SR subgroups across all participants based on two measures of SR. General linear models tested for SR group differences in clinical and biological parameters. Exploratory analyses examined associations between SR group-specific brain alterations and gene expression. The High, compared to Low SR group showed greater cyclic AMP response element-binding protein (CREB) gene expression consistent with tonic SNS activity and proinflammatory changes in whole blood. Neuroplastic brain changes were observed in the High SR group consistent with an upregulation of ascending arousal systems, sensory processing and integration regions, and functional connectivity changes in the central autonomic network. In IBS, SR moderated sex differences in extraintestinal symptoms. The findings support a model of tonically increased, unprovoked SNS activity as a plausible risk factor for increased reactivity to psychosocial stressors and low grade immune activation in both IBS and HCs, with a greater likelihood in IBS. These findings may have important implications for personalized treatment interventions in IBS.

Indexed as

CREB transcriptionDiffusion tensor imagingFunctional brain connectivityIrritable bowel syndromeProinflammatory genesStress reactivity

Identifiers

PMID42110977
PMCPMC13156650

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.