Evidence map›Paper›PMID 42110971›Full record

ArticleJBMR plus2026

Synergistic effects of diabetic neuropathy and kidney function decline on second metatarsal skeletal health and foot function: a pilot study.

Victor A Cheuy, Saghi Sadoughi, Hasung Moon, Jalen Ellis, Rodney Gross, David R Sinacore, Mary K Hastings, Richard B Souza, Galateia J Kazakia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victor A CheuyDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA 94143, United States.ORCID https://orcid.org/0000-0002-3033-2255
Saghi SadoughiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, United States.
Hasung MoonDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA 94143, United States.
Jalen EllisDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA 94143, United States.
Rodney GrossDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA 94143, United States.
David R SinacoreDepartment of Physical Therapy, High Point University, High Point, NC 27268, United States.
Mary K HastingsProgram in Physical Therapy, Washington University in St. Louis, St. Louis, MO 63108, United States.
Richard B SouzaDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA 94143, United States.
Galateia J KazakiaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, United States.ORCID https://orcid.org/0000-0002-7327-6425

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
MUSCLE, JOINT AND MOVEMENT DETERIORATION CONTRIBUTING TO NEUROPATHIC FOREFOOT DEFORMITYR01DK107809 · NIDDK · WASHINGTON UNIVERSITY · PI MARY K HASTINGS · 2016 to 2026
$4.3M
NCATS NIH HHS KL2 TR001870NCATS NIH HHS UL1 TR001872NIAMS NIH HHS P30 AR075055NIDDK NIH HHS R01 DK107809
6 · The paper itself

Abstract

A discouraging increase in diabetes-related nontraumatic lower-extremity amputations (NLEA) has occurred over the last decade. Individuals with diabetic neuropathy (DMPN) and CKD are at the highest risk for NLEA. Despite the critical implications, little is known about the factors that initiate the cascade of events leading to NLEA, limiting early and effective interventions. We aimed to develop and implement a technique for quantifying metatarsal bone density and microstructure using HR-pQCT. Twelve participants were enrolled:

Indexed as

amputationbiomechanicsbonediabetesfootHR-pQCTkidney diseasemineral bone disorderneuropathy

Identifiers

PMID42110971
PMCPMC13156507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.