Evidence map›Paper›PMID 42110967›Full record

ArticleJBMR plus2026

Comprehensive profiling of the competitive interplay among carbamylation, glycation, and enzymatic cross-links in human bone.

Shoutaro Arakawa, Shota Katayama, Hikari Sugawa, Taiki Neyatani, Yu Yamashita, Daisuke Kubota, Tomohiro Kayama, Hiroteru Hayashi, Teruyuki Miyasaka, Toshiyuki Omori and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shoutaro ArakawaDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID https://orcid.org/0000-0002-8932-8357
Shota KatayamaDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Hikari SugawaLaboratory of Food and Regulation Biology, School of Agriculture, Tokai University, Kumamoto 871-2205, Japan.
Taiki NeyataniDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Yu YamashitaDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Daisuke KubotaDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Tomohiro KayamaDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Hiroteru HayashiDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Teruyuki MiyasakaDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Toshiyuki OmoriDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Ryoji NagaiLaboratory of Food and Regulation Biology, School of Agriculture, Tokai University, Kumamoto 871-2205, Japan.
Mitsuru SaitoDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbamylation-derived products (CDPs) are implicated in protein dysfunction but remain understudied in human bone. We profiled homocitrulline (HCit, the predominant CDP), advanced glycation end-products (AGEs), and enzymatic cross-links in human cancellous bone specimens (

Indexed as

advanced glycation endproducts (AGEs)bone qualitycarbamylationCKDenzymatic collagen cross-linkshomocitrulline (HCit)

Identifiers

PMID42110967
PMCPMC13156504

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.