ArticleClinical interventions in aging2026
The Correlation Between Podocyte Senescence and the Clinicopathology in Elderly Patients with IgAN.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: IgAN is a common primary glomerular disease, and age may affect its clinical manifestations and progression. However, age-related differences in elderly IgAN, especially the role of podocyte senescence and the cGAS-STING pathway in elderly IgAN patients, remain incompletely understood. Patients and Methods: This retrospective study analyzed 1012 renal biopsy‑confirmed IgAN patients from January 2014 to January 2024, categorized into elderly (≥60 years, n=119) and younger (18-60 years, n=893)) groups after exclusion. Clinical, laboratory, and pathological data were collected. Kaplan-Meier survival analysis and Cox proportional hazard models were used to evaluate prognostic factors. Expression of the cGAS-STING pathway in renal tissues was detected to explore its association with podocyte injury. SASP in serum was detected by ELISA and qPCR. Results: Compared with the young IgAN group, the elderly IgAN group had higher levels of 24-hour urinary protein, urea and creatinine; lower hemoglobin and albumin; more severe tubular atrophy/interstitial fibrosis (T1/2 lesions, 47.1% vs. 23.9%); lower IgA immunofluorescence intensity; and more severe podocyte fusion. Kaplan-Meier analysis showed poorer renal outcomes in the elderly IgAN group ( Conclusion: Elderly IgAN patients exhibit distinct clinicopathological features dominated by chronic lesions and podocyte injury. Severe podocyte fusion (>50%) is a critical independent prognostic factor for this population. The cGAS-STING pathway may mediate age-related podocyte senescence and injury, representing a potential therapeutic target for elderly IgAN patients.
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