Sex-specific variations in subgingival microbiome of elderly patients with moderate periodontitis: an exploratory study.

Ya-Qiong Zhao, Bi-Fen Kuang, Marie Aimee Dusenge, Qiong Liu, Feng-Yi Zhang, Ying-Hui Zhou

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Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Ya-Qiong Zhao *Department of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Bi-Fen Kuang *Department of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Marie Aimee DusengeDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Qiong LiuDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Feng-Yi ZhangDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Ying-Hui ZhouDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

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6 · The paper itself

Abstract

Introduction: Periodontitis, a leading cause of alveolar bone destruction and tooth loss, is associated with oral microbiota dysbiosis and shows higher susceptibility in males than in females. This study investigated sex-specific variations in the subgingival microbiome of elderly patients with moderate periodontitis. Methods: Subgingival plaque samples were collected from 25 patients with moderate periodontitis (8 males, 17 females; aged 50-73 years). The microbial composition was analyzed using 16S rRNA gene sequencing (V3-V4 region). Functional prediction was conducted utilizing the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Results: Males exhibited higher Chao1 diversity, and beta diversity analysis revealed sex-based clustering. Wilcoxon rank-sum tests and LEfSe analysis identified Conclusion: This exploratory study observed sex-specific subgingival microbiome variations of elderly patients with moderate periodontitis. Females exhibited specific enrichment of

Indexed as

16S rRNA sequencingbone losselderlyperiodontitissex-specific variationssubgingival microbiome

Identifiers

PMID42110914

DOI10.3389/fgene.2026.1791446

PMCPMC13152674

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