ArticleAlpha psychiatry2026
Complete Blood-Count-Derived Inflammatory Markers Across Acute Mood Episodes.
Article in Alpha psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cumulative anticholinergic burden is associated with lower clozapine metabolic ratios: a cross-sectional study.BMC psychiatry · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recent evidence has suggested that low-grade systemic inflammation may contribute to the clinical expression of mood disorders, yet findings have differed considerably across studies. The present study compared several complete blood-count (CBC)-derived inflammatory indices among inpatients with bipolar disorder (BD), manic and depressive episodes, and major depressive disorder (MDD), and examined whether psychotropic medications influenced these inflammatory markers. Methods: This retrospective chart-review study included only inpatients hospitalized with a diagnosis of BD or MDD between January 1, 2019, and January 1, 2023. A healthy control (HC) group, matched by age and sex, was included for comparison. For data independence, only the first CBC obtained within 24 hours of admission was analyzed. Inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), were calculated from standardized fasting blood samples. Statistical analyses were performed using the Kruskal-Wallis test for group comparisons, followed by Bonferroni-corrected Mann-Whitney U tests. Additionally, analysis of covariance (ANCOVA) and regression models were employed to control for potential confounders such as age, sex, length of stay, and various psychotropic medications (lithium, antidepressants, and antipsychotics). Results: NLR and MLR ratios were consistently higher in all mood-disorder groups than in healthy individuals. PLR elevation appeared specific to the MDD group, and the SII was increased in depressive episodes but not in mania. These patterns remained statistically significant after adjustment for demographic covariates; male sex was negatively associated with PLR. Regression analyses adjusted for age and sex demonstrated a negative association between antidepressant use and PLR and MLR values. Conclusions: These results suggested that acute mood episodes are accompanied by measurable increases in certain inflammation-related hematologic markers. The inverse relationship between antidepressant use and PLR and MLR was consistent with an association between medication use and nonspecific systemic inflammatory markers observed in acutely hospitalized patients.
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