ArticleCirculation reports2026
Acute Decompensated Heart Failure Complicated by Ischemic Stroke and Its Association With Hemoglobin Levels.
Article in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
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Abstract
Background: Ischemic stroke (IS) is a serious but underexplored complication of acute decompensated heart failure (ADHF). We assessed the incidence, subtypes, and phase-specific association between hemoglobin and IS risk. Methods and Results: The West Tokyo Heart Failure Registry-2 is a prospective multicenter cohort enrolling consecutive patients hospitalized for ADHF at 11 tertiary hospitals in Tokyo (2018-2024). Board-certified neurologists confirmed IS and classified subtypes using the TOAST criteria. IS incidence and subtypes were evaluated during the early (≤30 days) and late (>30 days) phases after hospitalization relative to hemoglobin levels (anemic/non-anemic). Among 5,106 patients (median age 79 years; 58% male; median left ventricular ejection fraction 45%), 115 (2.3%; 3.6% per person-year) developed IS during a median 13-month follow-up. IS incidence peaked in the early phase, with a median onset of 7 days (interquartile range 3-12 days; P Conclusions: IS occurred most frequently within 30 days after ADHF hospitalization, and was predominantly cardioembolic. Non-anemia identified patients at higher risk of IS in the early phase, suggesting its potential value for early risk stratification.
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