ArticleCirculation reports2026
Association Between Severe Aortic Stenosis and Amyloid Deposition in the Myocardium of Patients With Wild-Type Transthyretin Cardiac Amyloidosis.
Article in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Cardiac amyloidosis: what every interventional cardiologist should know.Cardiovascular intervention and therapeutics · 2026Review
- Transthyretin Cardiac Amyloidosis in Women: Underdiagnosis, Sex-Specific Phenotypic Expression and Therapeutic Response.Journal of clinical medicine · 2026Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is frequently observed in older patients with aortic stenosis (AS), its relationship with AS is unclear. Therefore, this exploratory study aimed to investigate the relationship between myocardial amyloid deposition and AS in patients with ATTRwt-CA. Methods and Results: This study included 39 patients (mean age 76 years) with biopsy-confirmed ATTRwt-CA. Myocardial amyloid deposition was quantitatively analyzed using histological evaluation of the biopsied myocardium and the heart-to-contralateral (H/CL) ratio was evaluated using bone scintigraphy. These parameters were then compared between 5 patients with severe AS and 34 patients without severe AS, and predictors of severe AS were evaluated. Myocardial amyloid deposition was greater in ATTRwt-CA patients with severe AS than in those without severe AS (mean [±SD] 32.6±12.7% vs. 19.9±11.7%; P=0.0311) but there was no difference in the H/CL ratio between the 2 groups. Multivariate analysis identified only greater myocardial amyloid deposition (per 10%) as an independent determinant of severe AS in patients with ATTRwt-CA (odds ratio 2.91; 95% confidence interval 1.23-8.67; P=0.0254). Conclusions: This exploratory study suggests that severe AS may be associated with myocardial amyloid deposition in patients with ATTRwt-CA, although larger prospective research is needed to validate our results.
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