Evidence map›Paper›PMID 42110838›Full record

ArticleTransplantation direct2026

The Impact of Normothermic Machine Liver Perfusion on Early Renal Outcomes After Simultaneous Liver-kidney Transplantation: A Propensity Score-Matched Analysis.

Muhammad A Nadeem, Chase J Wehrle, Sangeeta Satish, Hafiz Umair Siddiqui, Sapana Verma, Valberto Sanha, Khaled Ali, Mazhar Khalil, Alejandro Pita, Jamak Modaresi Esfeh and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Muhammad A NadeemCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Chase J WehrleCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Sangeeta SatishCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Hafiz Umair SiddiquiDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.
Sapana VermaCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Valberto SanhaCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Khaled AliCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Mazhar KhalilCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Alejandro PitaCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Jamak Modaresi EsfehDepartment of Hepatology, Cleveland Clinic, Digestive Disease and Surgery Institute, Cleveland, OH.
David C H KwonCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Federico AucejoCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Jaekeun KimCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Antonio D PinnaDepartment of Liver Transplantation, Cleveland Clinic Weston Hospital, Weston, FL.
Mohamed EltemamyDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.
Charles MillerCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Masato FujikiCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Robert L FairchildDepartment of Inflammation and Immunology, Cleveland Clinic, Cleveland Clinic Research Institute, Cleveland, OH.
Richard A FaticaDepartment of Kidney Medicine, Cleveland Clinic, Cleveland, OH.
Koji HashimotoCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Alvin WeeDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.
Andrea SchlegelCleveland Clinic, Transplant Center, Transplant Enterprise, Cleveland, OH.
Cleveland Clinic Liver Perfusion Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: No study has assessed the effect of end-ischemic normothermic machine perfusion (NMP) on renal function in simultaneous liver-kidney (SLK) transplantation. We hypothesized that by mitigating liver ischemia/reperfusion injury, NMP exerts a renoprotective effect on kidney allografts. This study compares renal outcomes in SLK transplant recipients receiving NMP versus static cold storage (SCS) livers. Methods: We analyzed deceased-donor SLK transplant recipients (January 2019-July 2024) with at least 6 mo follow-up (n = 85). Primary outcomes included delayed graft function (DGF) and functional-DGF (f-DGF; failure of serum creatinine to decrease 10% daily for 3 d in the first week). Liver Core Outcome Sets were reported. NMP recipients (n = 17) were propensity score-matched 1:2 to SCS controls (n = 34). Kidneys underwent hypothermic machine perfusion in both groups. Results: Cohorts were well matched, although NMP had more donation after circulatory death donors ( Conclusions: In this cohort, NMP was associated with improved early renal recovery in SLK transplant recipients, characterized by lower rates of f-DGF and higher estimated glomerular filtration rate. These findings suggest that mitigating liver ischemia via NMP may provide secondary benefits to the simultaneous kidney allograft.

Identifiers

PMID42110838
PMCPMC13155494

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