ArticleACS omega2026
Synthesis and Characterization of Regenerated Cellulose Coated with a Silk Fibroin/Hydroxyapatite Scaffold for Enhanced Adhesion and Proliferation of Preosteoblast Cells.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
Biopolymer-based scaffolds are promising for tissue engineering due to their exceptional biocompatibility and biodegradability. This study synthesized biopolymer composite scaffolds involving regenerated cellulose extracted from sugarcane bagasse and silk fibroin (SF) at different concentrations. The scaffold was further coated with hydroxyapatite (HA) to evaluate its efficiency in promoting the growth of bone cells. The regenerated cellulose with HA and without SF was used as a control, and the scaffolds were characterized by various analytical techniques. The results from scanning electron microscopy showed a porous structure with a significant reduction in pore size from 220.04 ± 53.32 μm to 105.47 ± 27.68 μm, following the addition of 3% SF and HA coating. In addition, the percentage porosity and swelling properties decreased from 97.58 ± 0.25% and 1578.17 ± 94.17% to 92.29 ± 1.15% and 1213.36 ± 59.75%, respectively, for 3% SF and HA coating, with a biodegradation rate of 21.4 wt % in 28 days. The Brunauer-Emmett-Teller surface area decreased from 1.37 m
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