ArticleACS omega2026
Noncalcined Bioactive Glass/Fish Scale Gelatin Hybrids Prepared by Sol-Gel Processing for Enhanced
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Fish-derived biomaterials have attracted increasing interest for biomedical applications due to their biocompatibility and sustainability. In this study, fish scale gelatin was extracted through sequential acid-alkaline treatment followed by heat extraction at 75 °C and utilized to fabricate a composite scaffold with bioactive glass (BG). BG sol was synthesized from tetraethyl orthosilicate, triethyl phosphate, calcium nitrate, nitric acid, ethanol, and deionized water using a sol-gel method. The BG sol was blended with fish scale gelatin solution and stirred for 2 days to form a wet gel, which was subsequently oven-dried for 6 h to obtain fish scale gelatin/bioactive glass (FSG/BG) composites. The materials were characterized by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy with energy-dispersive X-ray (SEM-EDX), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Thermal analyses showed that the extracted gelatin exhibited behavior comparable to commercial gelatin. FTIR spectra confirmed the formation of Si-O-Si networks and the presence of characteristic protein functional groups in the composite. The compressive strength of the FSG/BG scaffold (7.63 MPa) was higher than that of pure BG (6.51 MPa), indicating improved structural integrity.
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