Evidence map›Paper›PMID 42110645›Full record

ArticleArchives of medical science : AMS2026

Aging and coronary artery calcification: a Mendelian randomization study.

Mateusz Lejawa, Marcin Goławski, Mateusz Olek, Nikodem Baron, Jacek J Jozwiak, Beata Maksym, Natalia Pawlas, Tadeusz Osadnik, Maciej Banach

Abstract read
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In one paragraph

Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mateusz LejawaDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Marcin GoławskiDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Mateusz OlekDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Nikodem BaronDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Jacek J JozwiakDepartment of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Poland.
Beata MaksymDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Natalia PawlasDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Tadeusz OsadnikDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Maciej BanachDepartment of Preventive Cardiology and Lipidology, Medical University in Lodz (MUL), Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Coronary artery calcification (CAC) is a recognized marker of atherosclerosis and cardiovascular disease (CVD) risk. While CAC is closely linked to aging, its potential as a marker of biological aging remains uncertain. Telomere length (TL), epigenetic aging markers, and dental deterioration parameters have been proposed as indicators of biological aging. However, the extent to which these biological aging indicators are associated with CAC remains unclear. Material and methods: Two-sample and three-sample Mendelian randomization (MR) analyses were conducted to investigate the potential causal effects of TL, epigenetic aging markers (intrinsic epigenetic age acceleration [IEAA], phenotypic age [PhenoAge]), and dental deterioration traits on CAC. Summary-level statistics from large-scale genome-wide association studies (GWASs) were obtained and analyzed using appropriate MR methods. Results: Genetically determined longer TL was significantly associated with lower CAC levels (IVW Conclusions: This study supports an inverse causal relationship between TL and CAC, reinforcing CAC as a biomarker of biological aging. Epigenetic aging markers and dental deterioration parameters were not significantly linked to CAC. Future studies should explore additional aging-related traits and refine the genetic instruments for epigenetic aging and dental health to further elucidate their potential roles in vascular aging.

Indexed as

biological agingcoronary artery calcificationepigenetic agingMendelian randomizationtelomere length

Identifiers

PMID42110645
PMCPMC13154796

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