ArticleArchives of medical science : AMS2026
The ketogenic diet alleviates neuronal ferroptosis in epilepsy via HDAC4/TFRC signalling.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Macrophage Polarization-Related Biomarkers in Epilepsy: Integrated Bioinformatics Analysis and Clinical Validation.Journal of inflammation research · 2026Article
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5 authors.
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Abstract
Introduction: Ketogenic diets (KD) recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. This study aimed to investigate whether a KD might, like dietary restriction, affect brain functions in epilepsy. Material and methods: Kainic acid (KA) injection was used to establish an epilepsy model Results: Epilepsy mediated iron accumulation- and lipid peroxidation-induced neuronal ferroptosis. Interestingly, KD treatment alleviated epilepsy as well as the accumulation of ferrous iron and lipid peroxidation, resulting in the inhibition of neuronal ferroptosis in epileptic models Conclusions: Collectively, KD protect against the ferroptosis of neurons in epilepsy via promoting HDAC4-mediated deacetylation and downregulation of TFRC. Therefore, KD may be a promising strategy for epilepsy.
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