ArticleArchives of medical science : AMS2026
Relationship between clinical characteristics and serum tumor markers in connective tissue disease with interstitial lung disease as the initial manifestation.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD), which seriously affects the prognosis of patients. The abnormal expression of tumor markers in non-neoplastic diseases may be related to the occurrence and development of CTD-ILD. This study aimed to explore the detailed clinical characteristics of CTD-ILD, and to analyze their association with serum tumor markers. Material and methods: The clinical data of 128 patients with CTD-ILD were retrospectively analyzed. Seventy-nine ILD patients without CTD were enrolled as the non-combined group. Clinical data included imaging manifestations, laboratory indices and tumor markers such as carbohydrate antigen (CA) 125, CA153, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and squamous cell carcinoma (SCC) antigen were collected. ROC curve analysis was used to assess the clinical value of these markers. Results: The proportion of clinical manifestations such as arthralgia, rash, Raynaud's phenomenon, dry mouth and dry eyes in the combined group was higher than in the non-combined group ( Conclusions: The main clinical manifestations for CTD-ILD patients were arthralgia, rash, Raynaud's phenomenon, and dry mouth and eyes. The combined detection of tumor markers had high evaluation value.
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