ArticleArchives of medical science : AMS2026
Effect of thymoquinone on cyclophosphamide-induced injury in the rat urinary bladder.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Introduction: Cyclophosphamide (CP) is a chemotherapeutic agent used to treat neoplastic diseases, but its side effects include hemorrhagic cystitis. Thymoquinone (TQ) is an active ingredient of Material and methods: Sixty rats were divided into 6 equal groups: untreated control (group A), TQ-treated with 10 mg/kg/day TQ for 10 days (group B1), TQ-treated with 100 mg/kg/day TQ for 5 days (group B2), toxicity control where 100 mg/kg CP was administered for 2 days (group C), CP + TQ-treated with the same TQ treatment as group B1 and 100 mg/kg CP for 2 days (group D1), and CP + TQ-treated with the same TQ treatment as group B2 and 100 mg/kg CP for 2 days (group D2). Rat urinary bladders were assessed histopathologically via hematoxylin and eosin (H&E) and Masson's trichrome stains and were evaluated for oxidative stress and cell death markers. Results: CP demonstrated significant reduction in glutathione reductase, and increased malondialdehyde levels and protein carbonylation (both Conclusions: TQ may ameliorate CP-induced oxidative injury in rat urinary bladder, via its antioxidant and antiapoptotic effects.
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