ArticleArchives of medical science : AMS2026
Upregulation of Foxo3a protects neurons against hypoxia-ischaemia injury.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Introduction: A series of transcription factors have been profiled in ischaemic stroke. Forkhead box protein O 3a (FoxO3a), which belongs to the family of transcription factors, is characterised by a forkhead DNA-binding domain. However, the role of FoxO3a and circFoxO3, which is encoded from FOXO3 gene in stroke, remains unelucidated. Material and methods: A rat model of middle cerebral artery occlusion (MCAO)/reperfusion was applied, and rat neuroblastoma B35 cells were treated with cobalt chloride to mimic cellular hypoxia Results: Brain infarction was enlarged in ischaemia/reperfusion compared with simple ischaemia treatment. The protein level of FoxO3a increased significantly in MCAO and subsequently decreased following reperfusion. Increased FoxO3a expression was also found in CoCl Conclusions: Both FoxO3a and circFoxO3 are upregulated in ischaemic stroke, which associates with the apoptosis pathway. Hence, FoxO3a and circFoxO3 might be protective factors against hypoxia/ischaemia-induced neuronal damage.
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