Evidence map›Paper›PMID 42110593›Full record

ArticleBlood immunology & cellular therapy2025

Comprehensive profiling of AML and T-cell states across disease stages in acute myeloid leukemia using spectral flow cytometry.

Mhd Yousuf Yassouf, Jessica L Root, Poonam N Desai, Nicole R Vaughn, Ferdinandos Skoulidis, Hussein A Abbas, Patrick K Reville

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood immunology & cellular therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mhd Yousuf YassoufDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.
Jessica L RootDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.
Poonam N DesaiDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.
Nicole R VaughnDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.
Ferdinandos SkoulidisDepartment of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX.
Hussein A AbbasDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.
Patrick K RevilleDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS L30 CA264665NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by clonal expansion of myeloid precursors, yet the interplay between leukemic and immune cells across disease stages remains poorly understood. Here, we used spectral flow cytometry and high-dimensional computational analyses to profile peripheral blood mononuclear cells from 72 patients with AML across 3 disease stages: newly diagnosed, remission, and relapsed/refractory. Clustering analyses identified stage-specific enrichment patterns in myeloid and lymphoid populations, with leukemic CD34

Identifiers

PMID42110593
PMCPMC13155423

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.