Evidence map›Paper›PMID 42110527›Full record

ReviewFrontiers in pharmacology2026

The dual functions of Ziziphi spinosae semen as medicine and food: origins, cross-domain applications, antidepressant metabolites, and pharmacological mechanisms.

Xia Shao, Mingzhe Huangfu, Ning Wang, Qi Zhang, Minghui Zhao, Wanqing Xie, Chengbo Zhang, Ting Ma

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xia Shao *School of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Mingzhe Huangfu *China Academy of Chinese Medical Sciences, Hospital of Guang'anmen Hospital, Jinan, China.
Ning WangResearch Department of Shandong University of Traditional Chinese Medicine, Jinan, China.
Qi ZhangSchool of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Minghui ZhaoInstitute of Chinese Medicinal Literature and Culture, Shandong University of Traditional Chinese Medicine, Jinan, China.
Wanqing XieSchool of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Chengbo ZhangInstitute of Chinese Medicinal Literature and Culture, Shandong University of Traditional Chinese Medicine, Jinan, China.
Ting MaSchool of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression, a serious mental illness prevalent globally, exhibits a strong clinical heterogeneity. Existing chemical drug treatments have significant limitations, necessitating the development of safe and effective new intervention strategies.

Indexed as

applicationbioactive metabolitesdepressionethnopharmacologyziziphi spinosae semen

Identifiers

PMID42110527
PMCPMC13154398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.