ArticleFrontiers in medicine2026
Safety and effectiveness of intravenous tranexamic acid for posterior lumbar interbody fusion in patients on preoperative anticoagulants: a retrospective case-control study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Tranexamic acid (TXA) is a hemostatic agent used in posterior lumbar interbody fusion (PLIF). However, reports on its use in patients on preoperative anticoagulants are scarce. This study evaluates the safety and efficacy of preoperative 1 g TXA in such patients. Methods: This study retrospectively analyzed the medical records of patients who underwent PLIF and had received anticoagulants within 1 week before surgery between January 2021 and June 2023. After general anesthesia, at 15 min before skin incision, patients who received intravenous TXA were recorded as the observation group ( Results: The surgeries were successfully completed. The incisions healed as grade A, and no DVT occurred. The IBL and PDV in the observation group were significantly lower than those in the control group ( Conclusion: For patients undergoing PLIF with preoperative anticoagulation, TXA administration appears safe and significantly reduces perioperative blood loss.
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