ArticleFrontiers in medicine2026
Afebrile brucellosis patients in endemic areas: a great diagnostic challenge.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Brucellosis is a common zoonotic infection in pastoral areas. The absence of fever in some patients can lead to misdiagnosis or underdiagnosis, resulting in delayed treatment. However, no literature have summarized the clinical features of afebrile brucellosis, and this study aimed to fill in the research gap. Methods: In this retrospective case-control study, patients diagnosed with brucellosis who were admitted to the Affiliated Kashgar Hospital of Sun Yat-sen University in 2024 were included. They were divided into afebrile and febrile groups. Demographic data, clinical features, and laboratory findings were compared between the two groups. Results: A total of 70 afebrile and 119 febrile patients were included in the study. Compared with febrile patients, afebrile patients had a higher proportion of chronic disease course (20% vs. 10%, Conclusion: The atypical clinical manifestations, lower positive rate of bacterial culture, and fewer abnormal laboratory findings pose a greater diagnostic challenge of afebrile brucellosis. Despite causing less systemic impact, afebrile brucellosis may be associated with a worse prognosis. Physicians in pastoral areas should emphasize etiological diagnosis for afebrile patients presenting with dorsalgia.
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