Evidence map›Paper›PMID 42110435›Full record

Trial reportFrontiers in medicine2026

Diminished plasma levels of GPIb-

Alice Bernard, Lina Maria Serna-Higuita, Karina Althaus, Peter Rosenberger, Robin Vöhringer, Andreas Körner, Helene Haeberle, Claudia Eggstein, Tamam Bakchoul, Andreas Margraf and 4 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03111212 (Therapeutic Iloprost for the Treatment of Acute Respiratory Distress Syndrome), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03111212 phase3completednot on this map

Therapeutic Iloprost for the Treatment of Acute Respiratory Distress Syndrome (ARDS) (the ThIlo-Trial)

TypeinterventionalSponsorUniversity Hospital TuebingenRan2019 to 2021Enrolled150ConditionsRespiratory Distress Syndrome, AdultArmsIloprost, control
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alice BernardDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.
Lina Maria Serna-HiguitaInstitute for Clinical Epidemiology and Applied Biostatistics (IKEaB), Tübingen, Germany.
Karina AlthausInstitute for Clinical and Experimental Transfusion Medicine, Medical Faculty, University Hospital Tübingen, Tübingen, Germany.
Peter RosenbergerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.
Robin VöhringerInstitute for Clinical Epidemiology and Applied Biostatistics (IKEaB), Tübingen, Germany.
Andreas KörnerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.
Helene HaeberleDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.
Claudia EggsteinDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.
Tamam BakchoulInstitute for Clinical and Experimental Transfusion Medicine, Medical Faculty, University Hospital Tübingen, Tübingen, Germany.
Andreas MargrafDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Christina FodiDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.
Alexander ZarbockDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Michael KoeppenDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.
Valbona MirakajDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Tuebingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Activated immune cells can interact with platelets and trigger the coagulation cascade in response to inflammatory stimuli, resulting in the formation of microthrombi which help contain the spread of pathogens, but also contribute to organ dysfunction. Platelet glycoprotein receptor GPIb- Methods: GPIb- Results: Cox analysis showed that low GPIb- Discussion: We are the first to report a role for platelet GPIb- Trial registration: EUDRA-CT: 2016-003168-37. Registered on 12/04/2017. ClinicalTrials.gov: NCT03111212. Registered on 04/06/2017.

Indexed as

ARDSbiomarkerGPIb-αimmunothrombosisplateletssepsis

Identifiers

PMID42110435
PMCPMC13153104

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.