Evidence map›Paper›PMID 42110367›Full record

ArticleInternational journal of pharmaceutics: X2026

Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability.

Annika Rautenberg, Paul Bühlbecker, Jan Kožák, Claire Chrétien, Yann Pellequer, Klaus Wunderling, Edmont Stoyanov, Alexander Pfeifer, Alf Lamprecht

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annika RautenbergDepartment of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.
Paul BühlbeckerDepartment of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.
Jan KožákDepartment of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.
Claire ChrétienUniversité Marie et Louis Pasteur, EFS, INSERM, RIGHT (UMR 1098), F-25000 Besançon, France.
Yann PellequerUniversité Marie et Louis Pasteur, EFS, INSERM, RIGHT (UMR 1098), F-25000 Besançon, France.
Klaus WunderlingInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.
Edmont StoyanovNisso Chemical Europe GmbH, Düsseldorf, Germany.
Alexander PfeiferInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.
Alf LamprechtDepartment of Pharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The design of free-flowing lyophilized powders by spray-freeze-drying (SFD) enables novel therapeutic applications, including nasal administration. In this study, a non-aqueous SFD approach using dimethyl sulfoxide (DMSO) as the spray solvent was investigated. Low-viscosity hydroxypropyl cellulose grades (HPC-SSL and HPC-UL) were employed as excipients to produce rapidly dissolving, porous, amorphous aprepitant powders at different drug-to-polymer ratios. The resulting spherical particles contained amorphous aprepitant and exhibited sizes between 250 μm and 500 μm.

Indexed as

Amorphous solid particlesFast absorptionNasal aprepitantOrganic freeze-dryingPorous particlesSpray-freeze-drying

Identifiers

PMID42110367
PMCPMC13156760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.