Evidence map›Paper›PMID 42110341›Full record

ReviewAdvances in hematology2026

Bispecific Antibodies in Hematologic Malignancies in the Outpatient and Community Settings.

Amrit S Gonugunta, Asad Haider, Virginia Mohlere, Mahmoud Aljurf, Shahrukh Hashmi, Muhammad Bilal Abid

Abstract readReview
In one paragraph

Review in Advances in hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amrit S GonuguntaDepartment of Internal Medicine, The University of Texas Health Science Center, Houston, Texas, USA, uth.edu.
Asad HaiderDivision of Hematology/Oncology, The University of Texas Health Science Center, Houston, Texas, USA, uth.edu.
Virginia MohlereDivision of Hematology/Oncology, The University of Texas Health Science Center, Houston, Texas, USA, uth.edu.
Mahmoud AljurfOncology Center, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia, co.bydgoszcz.pl.
Shahrukh HashmiDepartment of Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, UAE, ssmcabudhabi.ae.
Muhammad Bilal AbidCellular Immunotherapy and Blood & Marrow Transplant Program, Hematologic Malignancy Section, School of Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.ORCID https://orcid.org/0000-0002-1128-0445

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bispecific antibodies (BsAbs) are novel antitumor agents that simultaneously engage tumor-associated antigens with CD3 on endogenous effector T cells, leading to cancer cell death. The immune-mediated toxicity rates associated with BsAbs are considerably lower than those seen with CAR T-cell therapy. Hence, widespread utilization of BsAb products in outpatient and community settings will allow greater and more homogeneous access and thus improve patient outcomes. In this review, we discuss the unique toxicities associated with BsAbs currently approved by the U.S. Food and Drug Administration and provide a disease-agnostic framework for the safe community administration of BsAb therapy. With academic, community, and industrial partnerships, broader deployment of BsAbs could be streamlined. Education, provision of in-services, leveraging protocols and experiences, and development of templates and guidelines will make this transition smoother and allow every patient in need of BsAbs to receive timely access to these survival-prolonging therapies.

Indexed as

BiTEsBsAbsCAR-T therapycommunity practiceCRSICANSinfectionsoutpatienttoxicities

Identifiers

PMID42110341
PMCPMC13150839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.