ArticleJournal of public health research2026
Trends in sepsis-related mortality due to dermatologic infections in the United States: Demographic and geographic patterns from 1999 to 2023.
Article in Journal of public health research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Dermatologic infections complicated by sepsis represent a significant yet understudied cause of mortality in the United States, with evolving epidemiological patterns that warrant investigation. Objective: To examine nationwide trends in sepsis-related mortality due to dermatologic infections from 1999 to 2023, with focus on demographic and geographic disparities. Methods: This population-based retrospective study analyzed CDC WONDER mortality data using ICD-10 codes for dermatologic infections with sepsis. Joinpoint regression analysis calculated annual percentage changes (APCs) in age-adjusted mortality rates, stratified by gender, age, race/ethnicity, and geographic region. Results: Among 119,837 deaths, overall mortality showed statistically significant rise during 1999-2004 (APC: 9.05%, p<0.001) and 2012-2023 (APC: 4.72%, p<0.001), with a plateau during 2004-2012. Males showed steeper recent increases (2019-2023: APC: 6.64%, p<0.001) than females. The South region experienced the highest sustained increase (2012-2023: APC: 5.19%, p<0.001). Among racial/ethnic groups, Hispanic populations showed the most pronounced variations, with the highest initial increase followed by a statistically significant decline before rising again. Limitations: Reliance on death certificate data may introduce coding inconsistencies and underreporting. Conclusion: Sepsis-related mortality due to dermatologic infections shows concerning upward trends across most demographic groups and regions, highlighting the need for enhanced prevention strategies and targeted interventions for vulnerable populations.
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