Evidence map›Paper›PMID 42110223›Full record

ArticleObservational studies2025

Constrained Design of a Binary Instrument in a Partially Linear Model.

Tim Morrison, Minh Nguyen, Jonathan Chen, Michael Baiocchi, Art B Owen

Abstract read
In one paragraph

Article in Observational studies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tim MorrisonStatistics Stanford University.
Minh NguyenBiomedical Data Science Stanford University.
Jonathan ChenBiomedical Data Science Stanford University.
Michael BaiocchiEpidemiology and Public Health Stanford University.
Art B OwenStatistics Stanford University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We study the question of how best to assign an encouragement in a randomized encouragement study. In our setting, units arrive with covariates, receive a nudge toward treatment or control, acquire one of those statuses in a way that need not align with the nudge, and finally have a response observed. The nudge can be modeled as a binary instrument if one assumes that it affects the response only via the treatment status. Our goal is to assign the nudge as a function of covariates in a way that best estimates the local average treatment effect (LATE). We assume a partially linear model, wherein the baseline model is non-parametric and the treatment term is linear in the covariates. Under this model, we outline a two-stage procedure to consistently and optimally estimate the LATE. Though the variance of the LATE is intractable, we derive a finite sample approximation and thus a design criterion to minimize. This criterion is convex, allowing for constraints that might arise for budgetary or ethical reasons. We prove conditions under which our solution asymptotically recovers the lowest true variance among all possible nudge propensities. A one-stage version of the algorithm is consistent but not necessarily optimal. We apply our method to a semi-synthetic example involving triage in an emergency department and find significant gains relative to a regression discontinuity design.

Indexed as

Design of experimentsInstrumental variablesPartially linear modelsRandomized controlled trialsRegression discontinuity

Identifiers

PMID42110223
PMCPMC13155346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.