Evidence map›Paper›PMID 42110219›Full record

ArticleObservational studies2025

A Double Machine Learning Approach for Combining Experimental and Observational Studies.

Harsh Parikh, Marco Morucci, Vittorio Orlandi, Sudeepa Roy, Cynthia Rudin, Alexander Volfovsky

Abstract read
In one paragraph

Article in Observational studies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Data Fusion for Partial Identification of Causal Effects.Advances in neural information processing systems · 2025
    Article
  2. AAdvances in neural information processing systems · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Harsh ParikhBiostatistics Yale University.ORCID https://orcid.org/0000-0003-1927-8646
Marco MorucciPolitical Science Michigan State University.
Vittorio OrlandiStatistical Science Duke University.
Sudeepa RoyComputer Science Duke University.
Cynthia RudinComputer Science Duke University.
Alexander VolfovskyStatistical Science Duke University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental and observational studies often lack validity due to untestable assumptions. We propose a double machine learning approach to combine experimental and observational studies, allowing practitioners to test for assumption violations and estimate treatment effects consistently. Our framework proposes a falsification test for external validity and ignorability under milder assumptions. We provide consistent treatment effect estimators even when one of the assumptions is violated. However, our no-free-lunch theorem highlights the necessity of accurately identifying the violated assumption for consistent treatment effect estimation. Through comparative analyses, we show our framework's superiority over existing data fusion methods. The practical utility of our approach is further exemplified by three real-world case studies, underscoring its potential for widespread application in empirical research.

Indexed as

Data FusionExternal ValidityGeneralizabilityMachine LearningObservational Study

Identifiers

PMID42110219
PMCPMC13155357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.