ArticleCase reports in endocrinology2026
Severe Transient Central Diabetes Insipidus After Pituitary Adenoma Removal With Peak Urine Output of 33.5 L in 24 h.
Article in Case reports in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Severe Transient Central Diabetes Insipidus After Pituitary Adenoma Removal With Peak Urine Output of 33.5 L in 24 h.Case reports in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative central diabetes insipidus (CDI) is a well-documented but often transient complication following transsphenoidal surgery (TSS) for pituitary adenomas. CDI is characterized by excessive urine output due to impaired antidiuretic hormone (ADH) secretion following damage to the neurohypophyseal stalk or hypothalamus. While most cases resolve within a few days, severe cases with extremely high urine output are rare. This case is notable due to an exceptionally high urine output of 33.5 L in a single day, far exceeding typical postoperative presentations and highlighting the need for vigilant postoperative monitoring. Case Presentation: A 47-year-old female with hypertension and hypothyroidism underwent endoscopic endonasal TSS at Tribhuvan University Teaching Hospital (TUTH) for a pituitary macroadenoma compressing the optic chiasm. Within hours postoperatively, she developed significant polyuria exceeding 1000 mL/h, with urine osmolality of 213.3 mOsm/kg and hypernatremia (serum sodium 149 mmol/L), consistent with CDI. Urine output increased to 30.8 L on postoperative day 2 and peaked at 33.5 L on day 3, requiring aggressive fluid replacement and desmopressin therapy. Despite escalating doses of desmopressin, polyuria persisted before gradually resolving by postoperative day 5. Careful monitoring of electrolytes and stepwise adjustment of desmopressin led to stabilization, confirming transient rather than permanent CDI. Conclusion: This case highlights that postoperative CDI can present with extreme polyuria and rapid shifts in sodium and osmolality, making early recognition essential. It reinforces that individualized desmopressin titration and close fluid-electrolyte monitoring are critical to prevent complications and support full recovery, especially when urine output reaches unusually high levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.