Evidence map›Paper›PMID 42110120›Full record

ArticleJPGN reports2026

Return to baseline arsenic concentrations after 1 year on gluten-free diet in children with celiac disease: A prospective cohort study.

Nan Du, Clara Baek, Rachel Rosen, Tracy Punshon, Jocelyn A Silvester

Abstract read
In one paragraph

Article in JPGN reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Molybdenum-Closing the gap.JPGN reports · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nan DuDivision of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-2728-917X
Clara BaekDivision of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA.
Rachel RosenDivision of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA.
Tracy PunshonDepartment of Biological Sciences Dartmouth College Hanover New Hampshire USA.
Jocelyn A SilvesterDivision of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
TRAINING IN PEDIATRIC GASTROENTEROLOGY &NUTRITIONT32DK007477 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI Scott B Snapper · 1986 to 2026
$13.3M
The impact of upper gastrointestinal dysmotility on aspiration-associated aerodigestive disorders in childrenR01DK097112 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Rachel L Rosen · 2015 to 2026
$4.9M
Mechanisms and Markers of Small Intestinal Epithelial Injury and Villous AtrophyK23DK119584 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI SILVESTER, JOCELYN ANNE · 2019 to 2023
$971k
NCI NIH HHS P30 CA023108NIDDK NIH HHS K23 DK119584NIDDK NIH HHS R01 DK097112NIDDK NIH HHS T32 DK007477
6 · The paper itself

Abstract

Objectives: Lifelong adherence to a gluten-free diet (GFD) is the primary treatment for celiac disease (CeD). Concerns have been raised about increased exposure to contaminants in a GFD because rice, which naturally bioaccumulates arsenic and other environmental contaminants, is commonly used as a substitute for gluten. In this study, we aimed to determine whether elevated urinary arsenic and other heavy metal concentrations, previously observed after 6 months on a GFD, persisted after 12 months on a GFD. Methods: Single-center prospective longitudinal cohort study of children (age 2-18 years) with biopsy-confirmed CeD who initiated a GFD between January and May 2022. The primary outcome was the change in urinary arsenic concentration between baseline diagnostic endoscopy and 12 months on a GFD. Results: Twenty-one of the 35 (60%) participants provided a follow-up sample. After 12 months on a GFD, total median urinary arsenic concentration returned to baseline (3.42 vs. 4.93 μg/L, Conclusions: Children with CeD may have increased arsenic exposure as they transition to a GFD, but concentrations return to baseline within 1 year. Future studies are needed to identify dietary contributors and guide strategies to limit excess arsenic exposure.

Indexed as

environmental contaminantsheavy metalsmedically prescribed diet

Identifiers

PMID42110120
PMCPMC13151007

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.