ReviewCureus2026
A Comprehensive Review of the Pathophysiology and Management of Osteoarthritis: Emerging Therapeutic Strategies and Clinical Insights.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between imbalanced lower extremity muscle quality and the development of knee osteoarthritis: a Systematic Review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.Journal of translational autoimmunity · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis persists as a major contributor to chronic joint impairment, driven by progressive disruption of cartilage integrity, synovial activity, subchondral bone dynamics, and biomechanical stability. Its multifactorial nature links metabolic influences, inflammatory mediators, and mechanical loading patterns to the diverse spectrum of clinical manifestations and structural outcomes observed across affected individuals. This synthesis integrates current understanding of disease mechanisms with evaluation of established and emerging management strategies designed to support joint function and symptom control. Evidence was gathered through focused examination of literature published between 2015 and 2026, emphasizing diagnostic advances, pharmacologic and non-pharmacologic measures, surgical interventions, and regenerative modalities used in clinical settings. Key insights highlight evolving recognition of early molecular alterations, improved imaging sensitivity, and expanding interest in biological approaches capable of influencing cellular pathways involved in joint deterioration. Conventional therapies continue to offer substantial symptomatic benefit, although structural modification remains limited despite ongoing therapeutic exploration. Regenerative strategies, targeted molecular agents, and refined surgical techniques present promising avenues, yet inconsistent response patterns and limited long-term data indicate ongoing complexity in optimizing care. Overall, current findings illustrate notable progress in understanding OA progression and support continued refinement of diagnostic frameworks and treatment pathways to enhance precision and effectiveness across varied clinical presentations observed globally.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.