ArticleCureus2026
Intracranial Hemorrhage as the Primary Presentation of Metastatic Ewing Sarcoma: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
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Abstract
Ewing sarcoma (ES) is an aggressive malignant neoplasm that most commonly arises from bone or soft tissue in children and young adults. Although metastatic disease is frequently encountered, intracranial involvement is rare and often presents with nonspecific neurologic symptoms, creating diagnostic and management challenges. We report the case of a young adult with a known history of ES who presented with progressive neurologic decline. Neuroimaging revealed a large intracranial mass associated with extensive vasogenic edema and midline shift, prompting urgent neurosurgical evaluation. The patient underwent surgical intervention for decompression and diagnostic clarification, followed by multidisciplinary oncologic management. This case emphasizes the importance of maintaining a high index of suspicion for metastatic disease in patients with a history of ES who develop new neurologic symptoms. It also highlights the role of early imaging, timely neurosurgical involvement, and coordinated care in addressing rare intracranial manifestations of systemic malignancy. Recognition of this uncommon presentation is essential to guide appropriate management and improve clinical outcomes.
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