ArticleCureus2026
Seronegative Neuromyelitis Optica Spectrum Disorder in a Six-Year-Old Patient: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating disease of the central nervous system (CNS) in children. Its main clinical manifestations are optic neuritis and myelitis. In most cases, it is associated with suggestive magnetic resonance imaging (MRI) and positive serology (AQP4-IgG). We report a six-year-old girl with acute asymmetric quadriparesis, bilateral decreased visual acuity, and sudden loss of sphincter control. Although AQP4-IgG testing was negative, MRI demonstrated findings consistent with NMOSD. Consequently, she received high-dose methylprednisolone, intravenous immunoglobulin, and early rehabilitation, resulting in substantial neurological recovery. High clinical suspicion for NMOSD in children, particularly in the presence of bilateral optic neuritis and longitudinally extensive transverse myelitis (LETM), should prompt early treatment, even in seronegative cases, to prevent permanent neurological deficits.
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