ArticleCureus2026
Granuloma-Related Hypercalcemia Secondary to Silicone-Induced Granulomatous Lymphadenopathy: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granuloma-mediated hypercalcemia is an uncommon cause of parathyroid hormone-independent hypercalcemia and is usually associated with sarcoidosis, chronic infection, or other inflammatory disorders. Foreign-body granulomatous reactions caused by silicone are rare and may occur years after exposure. We report the case of a 77-year-old woman with recurrent hypercalcemia, generalized weakness, gait instability, nausea, abdominal discomfort, and weight loss. Biochemical evaluation showed suppressed parathyroid hormone, normal 25-hydroxyvitamin D, elevated angiotensin-converting enzyme, and inappropriately normal 1,25-dihydroxyvitamin D. Cross-sectional and functional imaging demonstrated paraoesophageal and right axillary lymphadenopathy. Mammography and targeted axillary ultrasound supported silicone migration, with the ultrasound showing a characteristic snowstorm appearance. Core biopsy confirmed breast tissue with fat necrosis and foreign-body giant cell reaction to silicone, with no evidence of malignancy. The overall findings supported silicone-induced granulomatous lymphadenopathy as the cause of parathyroid hormone-independent hypercalcemia. This case highlights the importance of taking a detailed prior implant or cosmetic exposure history when evaluating unexplained hypercalcemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.