ArticleCognitive neurodynamics2026
Rosmarinic acid mitigates age-related loss of EEG complexity in temporal cortex: a recurrence quantification analysis.
Article in Cognitive neurodynamics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Physiological aging is associated with progressive changes in brain function, including neural oscillations. Recurrence Quantification Analysis (RQA) may provide a nuanced perspective on neural dynamics in aging. Rosmarinic acid (RA) has shown promise in mitigating age-related neurodegeneration. Its effects on EEG complexity in aging models remain unexplored. This study aimed to investigate age-related changes in RQA metrics and to assess whether RA modulates these alterations in a rodent aging model. Aging was induced in female rats via D-galactose administration. RA was administered to aged model animals. Urethane-induced EEG were obtained and analyzed across delta and theta bands. RQA parameters-determinism (DET), entropy (ENTR), and laminarity (LAM)-were computed for frontal and temporal regions. Aging was associated with a significant increase in DET and LAM, particularly in the temporal cortex, indicating enhanced regularity and persistence of EEG patterns. Concurrently, ENTR values declined, suggesting reduced signal complexity. RA partially reversed these trends, notably decreasing DET and LAM while increasing ENTR values in the temporal cortex. No significant changes were observed in the frontal cortex. This study underscores the utility of RQA in capturing nonlinear EEG alterations associated with aging and highlights RA as a promising compound for preserving cortical dynamics in senescence. Supplementary Information: The online version contains supplementary material available at 10.1007/s11571-026-10457-9.
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